Nucleophilic Add.

Classic Method

Organolithium reagents are synthetically useful because they are great nucleophiles, strong bases, and effective catalysts for radical and anionic polymerizations. However, they often catch fire in the presence of air. To control these hazards, they are dissolved at low concentrations in ether solutions, which lessen the hazards, but are themselves dangerous.

ButylLithium Addition

Problems

Must be stored at cold temperatures to prevent decomposition
Available only at low concentrations in ether
Little selectivity and significant solvent waste
Many organolithiums are not commercially available and must be prepared at time of use

SiGNa’s Method

The SiGNa organolithium materials provide an extensive suite of nucleophiles that do not suffer from many of the traditional limitations. The SiGNa method increases selectivity and yield, while easing process setup, separation, and workup.

ButylLithium Addition

AllylLithium Addition

BenzylLithium Addition

Benefits

Allows for a smooth solution process in batch or continuous-flow reactors
SiGNa’s nucleophilic reagents are dry powders storable at room temperature for indefinite lengths of time
No highly flammable or hazardous solvents required
Increased selectivity and control of reaction