Nitrogen is central to medicinally-oriented organic synthesis, therefore it is important to be able to protect and deprotect them throughout a synthesis. However, the most useful nitrogen protecting groups, like sulfonamides, which provide high crystallinity are extremely difficult to remove in high yield through simple non-toxic methods.
Nitrogen deprotection using SiGNa materials effects clean desulfonation and deallylation utilizing a safe, smooth solution process. The SiGNa method improves yield and reaction conditions, provides milder conditions, and simplifies process purification.
Highly loaded, free-flowing stabilized alkali metal powders with reactivity as high as the parent metal.
Highly loaded, atomically dispersed alkali metal powder (includes lithium) wtih more extensive reactivity than the parent metal.
Currently SiGNa is working on the next element in the alkali metal family, Lithium. A number of new discoveries have been made. Read More