Deprotections
Classic Method
Nitrogen is central to medicinally-oriented organic synthesis, therefore it is important to be able to protect and deprotect them throughout a synthesis. However, the most useful nitrogen protecting groups, like sulfonamides, which provide high crystallinity are extremely difficult to remove in high yield through simple non-toxic methods.
SiGNa’s Method
Nitrogen deprotection using SiGNa materials effects clean desulfonation and deallylation utilizing a safe, smooth solution process. The SiGNa method improves yield and reaction conditions, provides milder conditions, and simplifies process purification.
Benefits
- Provides a smooth solution process at room temperature
- Highly selective allowing more options for substrate functionalization
- No toxic (i.e. mercury) or hazardous (i.e. liquid ammonia) materials needed
- No special equipment required for handling or processing
Recommended Products for Deprotections
Alkali Metal-Silica Gel
Highly loaded, free-flowing stabilized alkali metal powders with reactivity as high as the parent metal.
Alkali Metal-Alumina Gel
Highly loaded, atomically dispersed alkali metal powder (includes lithium) wtih more extensive reactivity than the parent metal.
SiGNa Spotlight
New Discoveries
Currently SiGNa is working on the next element in the alkali metal family, Lithium. A number of new discoveries have been made. Read More