Organolithium-Alumina Gel
Expand Your Organolithium Toolkit
Organolithium reagents are synthetically useful because they are strong bases, great nucleophiles, and effective catalysts for radical and anionic polymerizations. Such reagents are, however, very reactive, often spontaneously catching fire in air. To control these hazards, they are only commercially available as solutions in hydrocarbons or ethers, which cause challenges. Little can be done to modify the reactivity or selectivity of ordinary organolithium reagents, yet modification is a growing need in many chemical industries.
SiGNa Chemistry has transformed organolithium reagents into dry, free-flowing, stabilized powders in nano-structured alumina. These resulting powders perform all the reaction types of conventional organolithium compounds, such as nucleophilic additions, initiation of polymerizations, and base-catalyzed reactions, among others. The powders are infinitely stable under nitrogen gas at room temperature and extend the chemical toolbox of commercially available organolithium compounds.
Product Advantages
- Yield:
- Retains the same or better yield compared to typical organolithium reagents
- Kinetics:
- Performs nucleophilic additions and base-catalyzed reactions in diverse process conditions
- Ease of Use:
- Can be performed in batch and continuous flow processes and provides a broader selection of nucleophiles
- Safety:
- Removes the need for flammable storage solvents and is stable indefinitely at room temperature
- Cost:
- Higher reagent loadings from inexpensive starting materials
Typical Reactions
SiGNa Spotlight
New Discoveries
Currently SiGNa is working on the next element in the alkali metal family, Lithium. A number of new discoveries have been made. Read More